# https://hfgpr.com

> Human Functional Genomics Project Romania


## Posts

- [Human Functional Genomics Romania Conference September 3-4th 2025](https://hfgpr.com/hfgpr-conference/): Dear friends and colleagues, It is a great pleasure to invite you to join us on September 3-4, 2025, in the beautiful city of Cluj-Napoca for the First Conference of the Human Functional Genomics Romania initiative! The conference will bring together international experts to discuss cutting-edge aspects of theinteraction between the host, environment and the immune system that determine immunehomeostasis and the susceptibility to disease. At the same time, the conference will alsointroduce Human Functional Genomics Romania, a network of Romanian and internationalresearchers that focus their research on the identification of factors that modulate immuneresponses in populations from South-Eastern Europe. Human Functional Genomics Romania isalso affiliated and […]
- [Boosting Immune System Health: The Impact of Genetic Variations](https://hfgpr.com/post-2/): Engaging Introductions: Capturing Your Audience’s Interest Boosting Immune System Health: The Impact of Genetic Variations Image Description: A colorful illustration depicting the intricate connection between genetic variations and immune system health. The image showcases a DNA double helix structure, with various genetic variations represented by different colored strands. Surrounding the DNA structure are vibrant immune cells, symbolizing the crucial role of genetics in determining immune system function. The image aims to visually convey the importance of understanding genetic variations in order to enhance immune system health and combat human diseases. When it comes to our health, our immune system plays […]
- [Unraveling the Secrets of Human DNA: The Human Functional Genomics Project Romania](https://hfgpr.com/post-2-2/): Engaging Introductions: Capturing Your Audience’s Interest Unraveling the Secrets of Human DNA: The Human Functional Genomics Project Romania Have you ever wondered what makes you unique? What determines your eye color, your height, or even your susceptibility to certain diseases? The answers lie within your DNA, the blueprint of life. And thanks to the groundbreaking research being conducted by the Human Functional Genomics Project Romania, we are one step closer to unraveling the secrets hidden within our genetic code. In a world where technology is advancing at an unprecedented pace, the field of genomics has emerged as a game-changer. By […]

## Pages

- [pagina de proba](https://hfgpr.com/pagina-de-proba/)
- [ImmunAgeD](https://hfgpr.com/immunaged/): 1.     López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: An expanding universe. Cell 186, 243–278 (2023).2.     Accardi, G. & Caruso, C. Immune-inflammatory responses in the elderly: an update. Immun. Ageing A 15, 11 (2018).3.     Franceschi, C. & Campisi, J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J. Gerontol. A. Biol. Sci. Med. Sci. 69 Suppl 1, S4-9 (2014).4.     EUROSTAT. Ageing Europe. Ageing Europe https://ec.europa.eu/eurostat/cache/digpub/ageing/.5.     GHO | Global Health Observatory Data Repository (European Union) | Healthy life expectancy (HALE) – Data […]
- [FUSE](https://hfgpr.com/fuse/): 1.     Rudd, K. E. et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet Lond. Engl. 395, 200–211 (2020).2.     Evans, L. et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Crit. Care Med. 49, e1063 (2021).3.     Gotts, J. E. & Matthay, M. A. Sepsis: pathophysiology and clinical management. BMJ 353, i1585 (2016). Teams Our research team at the Medical Genetics Department of UMF Cluj-Napoca studies the mechanisms of inflammatory diseases and their interrelationship with individual genetic susceptibility factors. […]
- [RID-TB](https://hfgpr.com/rid-tb/): 1.        Global tuberculosis report 2022. https://www.who.int/publications-detail-redirect/9789240061729.2.        Streata, I. et al. The CARD9 Polymorphisms rs4077515, rs10870077 and rs10781499 Are Uncoupled from Susceptibility to and Severity of Pulmonary Tuberculosis. PLOS ONE 11, e0163662 (2016).3.        Cucu, M. G. et al. Polymorphisms in autophagy genes and active pulmonary tuberculosis susceptibility in Romania. Rev. Romana Med. Lab. 25, 47–53 (2017). Teams Our research team at the Medical Genetics Department of UMF Cluj-Napoca studies the mechanisms of inflammatory diseases and their interrelationship with individual genetic susceptibility factors. We are curious how the variance in our genome or […]
- [TanDeM-AGE](https://hfgpr.com/tandem/): 1.     Implications of the global increase of diabetes for tuberculosis control and patient care – Ruslami – 2010 – Tropical Medicine & International Health – Wiley Online Library. https://onlinelibrary.wiley.com/doi/10.1111/j.1365-3156.2010.02625.x.2.     Facts & figures. International Diabetes Federation https://idf.org/about-diabetes/diabetes-facts-figures/.3.     TB profile. https://worldhealthorg.shinyapps.io/tb_profiles/?_inputs_&entity_type=%22country%22&lan=%22EN%22&iso2=%22RO%22.4.     Immune aging in diabetes and its implications in wound healing – PMC. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322932/.5.     Esmail, H., Macpherson, L., Coussens, A. K. & Houben, R. M. G. J. Mind the gap – Managing tuberculosis across the disease spectrum. EBioMedicine 78, 103928 (2022). Teams Our research team at the Medical Genetics Department of UMF […]
- [SysScleRO](https://hfgpr.com/project-syssclero/): Teams Our research team at the Medical Genetics Department of UMF Cluj-Napoca studies the mechanisms of inflammatory diseases and their interrelationship with individual genetic susceptibility factors. We are curious how the variance in our genome or epigenome can alter the immunological processes and cause inflammatory disease. We assess immunological functions of primary cells in patient cohorts and in controls and we use multi-omics to assess the different molecular layers that can contribute to inflammatory dysregulation. Currently, we are investigating the mechanisms of immune memory associated to long term proinflammatory effects and accelerated immunological aging in gout, hyperuricemia, systemic sclerosis and […]
- [HINT-II](https://hfgpr.com/project-hint-ii/): Teams Our research team at the Medical Genetics Department of UMF Cluj-Napoca studies the mechanisms of inflammatory diseases and their interrelationship with individual genetic susceptibility factors. We are curious how the variance in our genome or epigenome can alter the immunological processes and cause inflammatory disease. We assess immunological functions of primary cells in patient cohorts and in controls and we use multi-omics to assess the different molecular layers that can contribute to inflammatory dysregulation. Currently, we are investigating the mechanisms of immune memory associated to long term proinflammatory effects and accelerated immunological aging in gout, hyperuricemia, systemic sclerosis and […]
- [HINT-I](https://hfgpr.com/project-hint-i/): Teams Our research team at the Medical Genetics Department of UMF Cluj-Napoca studies the mechanisms of inflammatory diseases and their interrelationship with individual genetic susceptibility factors. We are curious how the variance in our genome or epigenome can alter the immunological processes and cause inflammatory disease. We assess immunological functions of primary cells in patient cohorts and in controls and we use multi-omics to assess the different molecular layers that can contribute to inflammatory dysregulation. Currently, we are investigating the mechanisms of immune memory associated to long term proinflammatory effects and accelerated immunological aging in gout, hyperuricemia, systemic sclerosis and […]
- [Projects](https://hfgpr.com/projects/): Discover Our Research Projects
- [Contact](https://hfgpr.com/contact/): Get in touch Reach out to the Human Functional Genomics Project Find us at Email contacthfgpr@gmail.com Social Media Quick Answers Frequently Asked Questions
- [Blog](https://hfgpr.com/blog/)
- [Tools](https://hfgpr.com/services/): Tools Within our project, we gather various types of data using different tools and techniques. The most important ones are described below: Questionnaires are completed by all participants, including information about health status, diet, and lifestyle. DNA is isolated from EDTA blood, and multiple platforms are used for genomic analysis: Illumina SNP arrays, and whole exome sequencing is performed for some volunteers. DNA is available for extending genetic studies. The transcriptome will be evaluated in various settings: whole blood profiles (collected in PAXgene tubes), and in vitro after stimulation of peripheral blood mononuclear cells (PBMC) with different pattern recognition receptor […]
- [About](https://hfgpr.com/about/): Discover The Story Behind Our Research Projects About Us About the Human Functional Genomics Project Romania We have successfully identified genetic variations and their impact on human physiology and diseases HFGP Romania is a large-scale initiative dedicated to understanding the effects of genetic variations and the microbiome on the human body’s immune system and disease development. Our research projects delve into specific aspects and research questions to contribute to scientific knowledge and advance healthcare. Our Mission and Vision Inspiring Change Through Research and Collaboration Our Mission At the Human Functional Genomics Project Romania (HFGP Romania), our mission is to unlock […]
- [Home](https://hfgpr.com/): Latest News Tools Research, Discovery, and Advancements for Human Health Research Conducting cutting-edge research projects to unveil the mysteries of human genetics and microbiome Collaboration Partnering with renowned scientists, institutions, and stakeholders to accelerate discoveries in human health Communication Sharing insights, breakthroughs, and discoveries to inspire global collaboration in human functional genomics Join Our Mission to Transform Healthcare Why Choose Us Unlock the Potential of Your Genetic Blueprints Groundbreaking Research Leveraging state-of-the-art technologies to pioneer discoveries in human functional genomics Comprehensive Analysis In-depth examination of genetic variations and microbiome interactions for personalized health insights Global Collaboration Promoting cross-border collaboration to […]


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